What is cdc complement dependent cytotoxicity?

CDC (Complement Dependent Cytotoxicity) is a process in which antibodies bind with antigens on the surface of a target cell, triggering the activation of the complement system. The complement system is a group of plasma proteins that circulate in blood and are involved in the immune response against pathogens.

In the CDC process, the complement system produces a membrane attack complex (MAC) that forms on the surface of the target cell, leading to cell lysis or destruction. This process is mainly used in immunotherapy, where monoclonal antibodies are used to trigger the CDC response against cancer cells.

The CDC assay is a laboratory test that measures the ability of antibodies to activate complement and kill target cells. This assay is used to evaluate the efficacy of monoclonal antibodies in cancer therapy and is used in clinical trials to assess the potential of new cancer treatments.

CDC is an important mechanism of cell-mediated immunity, and its understanding and manipulation have great potential in the treatment of cancer and other diseases.